Freud predicted that at some point brain science would mature such that dynamic psychotherapy could re-join natural science. Some believe that this point has now been reached. In this lecture I will survey the burgeoning field of Affective Neuroscience with particular emphasis on the centrality of affect (feelings) to psychotherapy. Amongst others, I will explore the work of Jaak Panksepp and his research on affects and discuss how this feeling dimension is central to psychotherapy. This will hopefully stimulate lively engagement with what I believe will be an increasingly important field of research.