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Renal Safety Profile of Cobicistat-boosted Elvitegravir compared to Atripla or Atazanavir plus Emtricitabine/tenofovir DF in HIV-1 infected Patients

Renal Safety Profile of Cobicistat-boosted Elvitegravir compared to Atripla or Atazanavir plus Emtricitabine/tenofovir DF in HIV-1 infected Patients

Tenofovir DF ( TDF) has infrequently been associated with renal toxicity. Cobicistat (COBI), like ritonavir, can increase creatinine (Cr) without affecting glomerular filtration by inhibiting renal tubular creatinine secretion. We examined the renal safety of recently approved single tablet regimen STRIBILD [STB] (elvitegravir [EVG]/COBI/emtricitabine [FTC]/TDF). Pooled renal safety data through Week 48 were analysed from three STB studies (104,102, and 103) and Two COBI studies (105 and 114).

In the pooled STB studies, the median exposures to STB (n=749), ATR (n=375), and ATV/r+TVD (n=355) were 48, 59, and 48 weeks. The median (IQR) changes in Cr (mmol/L) at Week 48 in the three groups were 11.49 (5.30 to 19.44), 0.88 (-5.30 to 7.95), and 7.07 (0.88 to 15.02). The rates of renal AEs leading to study drug discontinuation (renal AE DC) were STB 1.1% (8/749), ATR 0 %, and ATV/r+TVD 0.3 % (1/355). One patient in STB reported a serious renal AE not leading to study drug discontinuation. In the pooled COBI studies, the median exposures to ATV/co+TVD (n=394) and ATV/r+TVD (n=377) were 48 weeks. The median (IQR) changes in Cr (mmol/L) at Week 48 in the two groups were 11.49 (4.42 to 19.44) and 7.95 (0.88 to 15.02). The rates of renal AE DC were ATV/co+TVD 1.5 % (6/394), ATV/r+TVD 1.6 % (6/377); two and three renal AE DCs from each group were serious AEs.
As expected, small increases in Cr were seen with the use of STB or COBI. The rates of renal event leading to study drug discontinuation with TDF-containing COBI-boosted EVG or ATV regimen were low at 1.2% (14/1143).

Speakers: Dr Mark Bloch
Conference: ASHM 2013
Areas of Interest / Categories: Australian Society for HIV 2013, HIV

Australian Society for HIV 2013

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Complex case report that illustrates the paucity of data for long term management of Visceral Leishmania-HIV co-infection.

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Regular HIV testing is recommended in men who take sexual risks. We assessed the relationship between perceived barriers to HIV testing, and frequency of testing among men who engaged in unprotected anal intercourse with casual partners (UAIC), to inform HIV testing strategies.

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In recent years there has been a widespread uptake of smartphones with internet access and location services and the development of mobile ‘apps’ for gay men to meet each other. We reviewed data collected in the Sydney and Melbourne Gay Community Periodic Surveys (GCPS) to identify which men were relying on mobile and internet methods to meet each other and whether these methods were associated with different risk practices.