Obesity and Cigarette Smoking are risk factors related to accelerate degenerative diseases in man which enhance precocious aging process. This condition states the heightened Oxidative Stress which is indicative for the changes made at the genetic materials level. Obesity and smoking increase the rate of telomere erosion per replication and occurring of inflammation which enhance leukocytes turn-over and shortened telomere arm length of leukocyte cells. Oxidative Stress induced extensive vascular endothelial cells dysfunction causing Vascular Diseases and other Degenerative Morbidities.
The male sex organ is the most frequent target organ for occurring Erectile Dysfunction (ED); ED pioneers other serious diseases queuing in the male holistic body system… ED indicates as “Gate-way” to other more serious Degenerative Diseases, such as; Critical limb ischemia, Hypertension, Dyslipidemia, Stroke, Cardio-Vascular-Diseases, Diabetes type-2, Kidney Failures, Hypogonadism and more…..
Hypogonadism accelerates the process of Precocious Aging; expressing Syndromes of Metabolic (METS) and Testosterone Deficiency (TDS). Endothelial Progenitor Cells (EPCs) Bone-marrow-derived EPCs has been well known for having the possibilities to regenerate sloughing off vascular- endothelium cells. EPCs have demonstrated the beneficial effects on ischemic induced vascular damage and recover ischemic tissues and organs. DHEA and Phospho-di-esterase-type-5i (PDE-5i)
Our current preliminary trials show: 1. DHEA enhance bone-marrow EPCs production in smokers and obese male hypogonadism with ED. 2. Combined daily consumption of DHEA and low dose PDE- 5i opens a new window to promote production of low levels EPCs in obese male hypogonadism and smokers with ED. Further trials with larger subjects and prolong periods of trial is recommended.