It has been hypothesised that buccal administration of testosterone (T), by preventing first-pass catabolism by the liver, may be a viable alternative to gels, patches and injectables. This abstract compares the pharmacokinetic/clinical pharmacological profiles of several routes of administration. Two studies were undertaken. In both Striant (30mg testosterone buccal system) was administered twice daily (at circa 08.00 and 22.00). In one 14-day, open label study in 26 hypogonadal males at 4 sites a comparison was made with Androgel (5g containing 50mg T ), daily. In the second in 67 patients at 5 sites the comparison was with Androderm (5mg) and /or Andropatch (5mg) for 7 days.
In the first, starting from similar baselines, Striant and Androgel produced equivalent increases in T levels (Cavg (0-24) 4.8 and 4.4 ng/ml, respectively). The percentage of patients achieving Cavg (0-24) within the normal range were 92% and 83% for the buccal and gel formulations respectively, with 84% (buccal) and 75% (gel) remaining within the normal physiological range over any 24hr period. In contrast, differences were observed between Striant and patch delivery. In particular, the T Cavg (0-24) achieved for Striant was much higher (5.4+/-1.7ng/ml) than that for patches (3.5+/-1.6ng/ml) a difference which was reflected in the percentage of patients achieving physiological levels (97% and 56% respectively for buccal and patch delivery systems).
Based on pharmacokinetic and/or clinical pharmacology parameters, Striant has an equivalent profile to T gel and a profile superior to that obtained using patch technology.
Sexually traumatized patients often have problems with flashbacks, nightmares and avoidance. This workshop teaches an integrated method for trauma relief, combining knowledge from NLP, psycho dynamic therapy, cognitive therapy and modern trauma research. The method is based on the human memory storing system, which functions in the same way in all human beings. This means that the method easily can be used cross-culturally and for all gender combinations.
To explore how sexual health and sexual ethics are represented in the Bible and how these are relevant to the 21st century. God created humans as physical and relational beings. Sexuality is a good, healthy element of that created physical relatedness, with three functions: relational bonding; mutual pleasure; and procreation. The biblical pattern for sexual expression which best accords with these functions is heterosexual monogamy.
How should the Public Health Model be applied so it really contributes to improved sexual health for all? Public Health recognizes three levels of prevention - Primary, Secondary and Tertiary. Primary prevention involves prevention of the disease or injury itself, Fluoride, Immunization, Education to avoid smoking and substance abuse. Secondary prevention blocks the progression of an injury or disease from an impairment to a disability. An impairment has already occurred, but disability may be prevented through early intervention.
The UK has among the highest teenage pregnancy and STI rates in Western Europe and strategies to reduce these outcomes have a high priority. This paper seeks to draw lessons from the rigorous evaluations of three sexual health initiatives: SHARE (a cluster randomised trial (CRT) of teacher-delivered sex education), RIPPLE (CRT of peer-delivered school sex education) and Healthy Respect Phase 2 (a quasi-experimental study of a multi-component Scottish national sexual health demonstration project encompassing youth friendly sexual health drop-ins, social marketing, branding, a parenting component and SHARE).
This symposium will focus on presentation of the results and discussion of a ground-breaking study into the cost and cost-effectiveness of sexuality education (SE) in six countries, commissioned by UNESCO in 2010. Why an economic analysis? Policy-makers all over the world, involved in decisions on school-based sexuality education (SE) programmes, are facing three important economic questions: what are the costs of developing the programmes, what are the costs of implementing and scaling up the programmes, and do the programmes provide value for money?
This presentation, "Responding to the needs of consumers with complex trauma histories a consumer perspective" focuses on the needs of adult survivors of child abuse, highlighting the frequent