Men treated with Androgen Deprivation Therapy (ADT) have a further decline in their ability for sexual intercourse and a decrease in sexual desire compared with men who are not treated with ADT. On the other hand, antiandrogen mono-therapy and Intermittent Androgen Deprivation (IAD), have been shown to be associated with significantly better sexual function outcomes.
Pre-treatment counselling should include pre-diagnosis sexual activity assessment, as well as patient and partner education and inclusion in treatment decisions. Post treatment management should include additional sexual health discussions and the offering of psychological, pharmacological, and if necessary, mechanical aids that can mitigate secondary sexual problems. Physicians should reduce known factors; explain to the patients the risks and benefit of the therapy, and work multi-disciplinary to achieve the optimal benefit for their patients.
The commonest male ejaculation disorder is Premature Ejaculation (PE). Inhibited or Delayed Ejaculation can be a more challenging condition to assess and treat. This discussion will focus on the diagnosis, investigations and management of ejaculation problems including an overview of the first medication specifically approved for the treatment of PE, dapoxetine, released under the trade name of Priligy™.
Androlife is the first Italian national campaign, supported by Italian Society of Andrology and Medical Sexology (SIAMS) aimed to: promote the primary prevention of the reproductive male tract pathologies, inform boys about the importance of controlling risk factors for male infertility, sensitize public awareness about male reproductive health, collect data on lifestyle, habits, and general health status in young males aged 18 to 35, and diagnose possible andrological pathologies.
Obesity and Cigarette Smoking are risk factors related to accelerate degenerative diseases in man which enhance precocious aging process. This condition states the heightened Oxidative Stress which is indicative for the changes made at the genetic materials level. Obesity and smoking increase the rate of telomere erosion per replication and occurring of inflammation which enhance leukocytes turn-over and shortened telomere arm length of leukocyte cells. Oxidative Stress induced extensive vascular endothelial cells dysfunction causing Vascular Diseases and other Degenerative Morbidities.
The total number of sexual activities for an individual varies greatly across the lifespan. The driving forces for sexual behaviour remain contentious with the role of androgens, other hormones, neurotransmitters and physiological factors often considered to be key components. Increasingly, scientific advances have attempted to provided explanations for understanding differences that have been attributed to factors such as genetic variations in CAG repeat polymorphisms or brain neuronal networks and these will be explored. However, emotional and relational problems may have equal or greater impact and there are concerns about the limitations of the medical model to explain sexual ‘differences’ and diversity.
A significant advancement in plant derived medicines in the last two centuries in such areas as central nervous system, anti-tumor and anti-inflammatory activities has led to the development and identification of active chemicals and understanding of their modes of action. As for man’s health related to sexuality, numerous age-old natural products have been historically claimed as ‘aphrodisiacs’ – a collective meaning, which describes improvement of arousal, libido and/or sexual energy and activity. It would appear that most natural herbal preparations considered as aphrodisiacs are acting like synthetic anabolic hormones. Sometimes, they are considered as a form of testosterone replacement therapy (TRT) since some of them are shown to stimulate the body to produce natural testosterone and even DHEA.
Aim: Studies have shown sexual dysfunctionality in 20-25% of infertile couples. Polycystic Ovarian Syndrome (PCOS) is the most common hormonal disorder among women of reproductive age and is a leading cause of infertility. Infertility may alter a woman’s sexual expression by causing or exacerbating sexual problems as a consequence of the diagnosis, investigation and treatment of infertility. Adequate sexual function can contribute to the success of fertility treatments. This study aims to assess sexual function in infertile and PCOS women in relation to their age, body mass index and duration of infertility. The prevalence of Female Sexual Dysfunction (FSD) and PCOS in infertile women and its correlation with infertility was also evaluated. And to find the relationship between Female Sexual Dysfunction and testosterone levels in women with Polycystic Ovary Syndrome (PCOS).
The age-related reduction in blood serum testosterone (T) level is well known as hypogonadism. Laboratory biochemical reports in healthy male youth has been reported to contain total-T ranging 250 - 800 mg/L. 60% are tightly bound to SHBG (sex-hormone-binding-globulin), 38% to albumin and in small fraction (2%) only is unbound and known as “free-T”. Consequently, only albumin-bound and free-T constitute the bio-available form of T, which are accessible to target tissues and carry out the actions of essential sex hormone, which also care for sexual function such as libido and mechanism of penile erection. This bioavailability of T concentration is influenced by SHBG levels. Aging men experience increase in aromatase activity and an elevation in SHBG production. The net result is an increase in the ratio of estrogen to T and decrease in total-T and Free-T. Free-T is essential for De-Hydro-Testosterone (DHT) production needed to cross the blood-brain- barrier to stimulate the TARGET aggressive-centre in the brain which provokes libido. Our former studies have shown that Tribulus terrestris L extracts containing the active agent PROTODIOSCIN can be converted to bioidentical DHEA, which may activate the conversion of albumin-bound-T to active Free-T and total-T presence of 5-alpha-dehydrogenase. Experiment with Protodioscin on Hypogonadic men with ED