A 28 year old man presented to my sexual medicine practice with a 4 year history of malaise, feelings of weakness and concentration problems following orgasm, whether it be masturbation or nocturnal emission. He has thus become avoidant of all sexual activity. His diagnosis fits the description of this syndrome which was originally described by the Dutch neuro-psychiatrist Marcel Waldinger and called Post Orgasmic Illness Syndrome. There appears to be an auto-immune or allergic basis to the condition. The patient was referred to an allergy clinic. The treatment outcome and nature of this rare condition of POIS will be discussed.