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Can Neuropsychological Profile (RBANS) Predict Co-Morbid Traumatic Brain Injury and Psychosis?

Can Neuropsychological Profile (RBANS) Predict Co-Morbid Traumatic Brain Injury and Psychosis?

NOTE: Only available in Mp3 audio file.
Traumatic insanity has been acknowledged since Meyer (1904), however, Psychosis Following Traumatic Brain Injury (PFTBI) has received modest empirical investigation, and is subsequently poorly understood, identified, and treated. Systematic and standardised neuropsychological research of PFTBI has not been reported, with work relying on retrospective chart reviews, case studies, and loosely defined self-reported Traumatic Brain Injury (TBI).

Objectives: To determine whether dually diagnosed patients with PFTBI have a unique neuropsychological profile relative to patients with a brain injury or a psychosis (schizophrenia).
A detailed cognitive neuropsychological battery was given to four groups; PFTBI (N=10), TBI (N=10), schizophrenia (N=23), and healthy controls (N=23). Discriminant Function Analysis (DFA) was conducted to determine whether scores could correctly classify the cohorts. Measures were excluded as predictor variables where no group differences were shown in group-wise comparisons, and/or where the distribution was non-normal. Final predictor variables were The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) Total index score and the Stroop Colour Trial Score.

The linear combination of predictors significantly differentiated the four groups; Wilks’s .= .49, .² (6, N = 65) = 43.42, p < .001. Approximately 49% of the variance was explained. Neuropsychological status was a moderate predictor of group membership. The pattern of misclassifications revealed that PFTBI cognitive neuropsychological performance is most like the profile shown in schizophrenia.

NOTE: only available in Mp3 audio file.

Conference: ASC 2013, MAPrc
Areas of Interest / Categories: ASC 2013, MAPrc 2015

MAPrc 2015

Maternal immune activation impacts on the kynurenine pathway in preadolescent offspring: Preventive effects of anti-inflammatory treatment.

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The Epidermal Growth Factor system in schizophrenia and its relation to treatment resistance

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Altered cell migration in patient-derived stem cell model of schizophrenia.

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Interaction of maternal immune activation and adolescent cannabinoid exposure enhances changes in miRNA expression in the adult entorhinal cortex.

Post-mortem analyses of cortical brain tissue in schizophrenia have been shown to display epigenetic changes that reflect early life experience. These affect the regulation of gene expression at the level of transcription, through changes in chromatin structure; and post-transcriptionally through non-coding RNAs, such as microRNA (miRNA). The aim of the current study was to investigate the role of miRNA in the brains’ response to maternal immune activation and adolescent cannabis exposure, alone and in combination, as both have been identified as environmental risk factors for schizophrenia.

Common polymorphisms in dopamine related genes combine to produce a “schizophrenia-like” prefrontal hypoactivity

The dopamine system plays a crucial role in mediating cognitive and affective processes. Aberrant dopamine neurotransmission is also thought to underlie the symptoms of schizophrenia. Dopamine-dependent prefrontal response relies on the regulation of both dopamine availability and the relative balance of D1/D2 receptor mediated action. This study aimed to determine the extent to which the catechol-O-methyltransferase (COMT) val108/158met (rs4680) and dopamine D2 receptor (DRD2) G-T (rs2283265) polymorphisms combine additively to determine prefrontal brain activity during cognitive-affective processing in healthy people and in schizophrenia.