Results are reported for synchrony at baseline, over the first 150 ms and then over the 250-350 ms window. Subjects with FEP were compared to control subjects matched for age, gender and years of education. The correlations between gamma synchrony and cognitive and clinical factors are reported. Raised gamma synchrony was observed in the subjects with first episode psychosis both centrally and fronto-temporally. These results were consistently observed at baseline, 0-150 ms and 250-350 ms.
After correction for multiple comparisons no correlations were observed between gamma synchrony and either neurocognition or symptomatology. Gamma synchrony abnormalities are present from early in the course of a psychotic illness and can be reliably demonstrated. However, the association of this basic measure of cortical activity and distal and complex cognitions and behaviours is weak or absent.
