HPV16 causes ~75% of HPV-associated anal cancer. Homosexual men are at greatly increased risk, but there are few data on the seroepidemiology of HPV16 in this population. We aim to determine the prevalence, incidence and risk factors for HPV16 seropositivity among community-based cohorts of homosexual Australian men.
1427 HIV negative men had sera collected annually from 2001 to 2007. 245 HIV positive men had sera collected annually between 2005 and 2007. Antibodies to HPV16 L1 were tested using multiplex type-specific Luminex serology. HPV16 seroprevalence, and seroincidence per 100 person-years (PY) in those initially HPV16 seronegative were calculated. Predictors of seroprevalent HPV16 were analysed by logistic regression and predictors of seroincident HPV16 by Cox regression for HIV negative participants.
A quarter (25.4%, 95% CI 23.1-27.9%) of HIV negative participants were HPV16 seropositive at baseline compared with nearly half of HIV positive participants (44.3%, 95% CI 37.4-51.5%). In contrast, HPV16 seroincidence was more than twice as high among HIV negative (3.1/100PY, 95% CI 2.5-3.8/100PY) as HIV positive men (1.3/100PY, 95% CI 0.3-5.2/100PY). In multivariate analyses, seroprevalent HPV16 was associated with more lifetime male partners (p=0.002), longer duration since first anal sex (p<0.001), preference for receptive role during anal sex (p=0.032), past infection with hepatitis B (p=0.035), positive HSV1 (p=0.034) and HSV2 (p=0.042) serology. In multivariate analyses, seroincident HPV16 was associated with younger age (p=0.004), reporting more recent male sexual partners (p=0.008) and unprotected anal intercourse with HIV positive or status unknown partners (p=0.021).
HPV16 seroprevalence was higher among HIV positive men, but HPV16 seroincidence was higher among HIV negatives. HPV16 seroincidence did not decline until after 34 years, suggesting that vaccination may be protective in many men under age 35. Both seroprevalence and seroincidence correlated well with markers of high risk sexual activity, particularly receptive anal sexual practices.
Over the past 20-30 years, the Premature Ejaculation (PE) treatment paradigm, previously limited to behavioural psychotherapy, has expanded to include drug treatment. Animal and human sexual psychopharmacological studies have demonstrated that serotonin and 5-HT receptors are involved in ejaculation and confirm a role for SSRIs in the treatment of PE. Multiple well-controlled evidence-based studies have demonstrated the efficacy and safety of SSRIs in delaying ejaculation, confirming their role as first-line agents for the medical treatment of lifelong and acquired PE. Daily dosing of SSRIs is associated with superior fold increases in IELT compared to on-demand SSRIs.
Despite high rates of screening and treatment in many remote Indigenous communities in Australia, diagnosis rates for sexually transmitted infections (STI), chlamydia and gonorrhoea in particular, remain alarmingly high. One contributing factor may be the high rate of temporary mobility for residents of remote communities. We use mathematical modelling to explore the impact of mobility on STI transmission within remote communities.
In 2006 two new innovative features were added to the WhyTest website; the ‘Tell them’ service allowing visitors to forward anonymous e-postcard or short message services (SMS) to sexual partners who may have been exposed to an STI, and the ‘remind me’ service allowing visitors to register for a 3, 6 or 12 monthly SMS reminder for a sexual health check. We describe the usage of the new website functionality, and recognition of a health promotion campaign conducted in January-June 2007 to promote these new features.
This symposium presentation will discuss conceptual approaches to how processes underway to develop the Australian Curriculum might link to improved sexual health outcomes. It will also explore the assumptions underpinning the ‘partnership’ between health and education sectors to uncover both the opportunities and the pitfalls for those who want to promote young people’s learning.
Human papillomavirus (HPV) induced oropharyngeal squamous cell carcinoma is a unique subtype of oropharyngeal cancer. It has a significantly better prognosis than that caused by tobacco and/ or alcohol. The incidence of HPV related oropharyngeal cancer is raising in the western countries.
ACCEPt is a multi-state cluster randomised trial that aims to increase annual chlamydia testing in 16-29 year olds attending general practice. 54 postcodes (80% in rural areas) are being randomised to a multi-faceted intervention and GP clinics within each postcode enrolled. The primary outcome is change in chlamydia prevalence, and a prevalence study is being conducted at the beginning and end of the trial. We report on the findings of the baseline prevalence study.
Surgery for gender dysphoria was not routinely available prior to the 80’s, surgery and psychiatry having had an unhappy liaison. While gender dysphoria is DSM classified it’s not because it is deemed to be an illness, rather than to give guidelines as to establishing a diagnosis, and surgery is now deemed to be an appropriate activity.
This presentation, "Responding to the needs of consumers with complex trauma histories a consumer perspective" focuses on the needs of adult survivors of child abuse, highlighting the frequent