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Altered epidermal growth factor receptor levels in dorsolateral prefrontal cortex may be implicated in suicidality in schizophrenia.

Altered epidermal growth factor receptor levels in dorsolateral prefrontal cortex may be implicated in suicidality in schizophrenia.

There was no difference in mRNA expression between patients and controls using ISH or qRT-PCR. Protein levels were highly significantly correlated with mRNA levels in SCZ (r=0.57, p=0.0002) and healthy controls (r=0.71, p=0.0001). In SCZ, those who had no history of suicidality had significantly higher levels of EGFR protein (0.24±0.07) and mRNA (0.872±0.03) compared to those with suicidality (-0.13±0.10;0.734±0.06).

EGFR protein but not mRNA levels are increased in the DLPFC in SCZ indicating a post-transcriptional dysregulation of effect. The pronounced effect of EGFR levels in suicidality and our data implicating clozapine augmentation of EGFR signalling suggests this may be a relevant mechanism in mediating the drug’s anti-suicidal properties.

Areas of Interest / Categories: ASPM 2014, ISHHR 2011, Meeting 2012

ISHHR 2011

War and trafficking: Supply and demand of trafficking.

In 2000, 120 nations took a stand against all forms of human trafficking through the Palermo Protocol to Prevent, Suppress and Punish Trafficking in Persons, especially Women and Children and encouraged

War and Trafficking: Migrant, trafficked and bonded workers and the business of organ harvesting.

The present-day abuses of migrant labour, human trafficking and bonded labour worldwide deserve long-overdue investigation by business academics into their causes and dynamics. Utilising data from

Group intervention with children

This article aims at reflecting, in the style of a story and not as a scientific or scholarly article, on a group therapy intervention with children of urban slums of Lima, populated by migrants from

The rise of juvenile crime in Georgia

Violence among the adolescents and adolescent delinquency often results in criminal charges and 14-18 year olds end up in the penitentiary facility. By the year 2005 only 26 adolescents were serving sentence in special juvenile facilities; however from 2006 onwards their number has increased drastically. At times the numbers of inmates reached 200, while today 162 juveniles are serving sentence. The rise of juvenile crime has become a debate issue for various groups of the Georgian society – education experts, psychologists, politicians are looking for the reasons of the situation at hand. We attempted a study of the demographic, social and academic profiles of adolescent inmates (the study of the Ministry of Education and Science, 2009), also taking into account our 5-year practice of working with juvenile convicts, which was aimed at supporting their resocialization and future reintegration into the society. In this work we will present a psychosocial portrait of an adolescent in the penitentiary system and consider the particular stress-factors that affect the juveniles and are determined by the specific features of the Georgian criminal subculture. We will also present 5 psychotypes of the adolescents in conflict with the law that were determined by the Freiburg personality test and will try to describe the self perception of the convicts while in confinement and after their sentence is served.

Case studies from GCRT of victims of war and other types of violence

During our work in GCRT for years we attained significant experience in psycho-traumatology. In contemporary concept of psycho-traumatology a human is referred to as a bio-psycho-social being. In trauma, its psychological and physical integrity are infringed. Person: soul and body is one whole, so it's very important to treat a person at every level through holistic and multidisciplinary approach. Our goal is to present cases of our beneficiaries, who were victims of war and other types of violence and developed different kind of psycho-traumatic disorders. We would like to share our experience of treating and rehabilitating body and psyche as one whole. Several cases (rehabilitation process and results) are discussed. In each presented case psycho-traumatic disorders have been diagnosed and confirmed clinically.

Stress factors in post-soviet period 1989-2011

The Collapse of the soviet system caused prolonged political, economical and psychosocial difficulties for the society. On one hand, collapse of totalitarian regime gives opportunity for change and

Research on trauma brought on by the disappearance of a child

Research on trauma brought on by the disappearance of a child is rare. The aim of our study was to increase understanding of uncertainty's role in the lives of those it affects, to present a narrative structure of the parents' testimonies, and to discern the origin of hope still felt by the parents. Sampling and Methods: Close reading and qualitative analysis of 29 testimonies given by parents whose sons disappeared during the Croatian War for Independence. Gender differences, categories, and frequencies of adjectives used were determined.