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Long term GnRHR treatment effects on autonomic nerve system and frontal lobe function in children with pubertas precox

Long term GnRHR treatment effects on autonomic nerve system and frontal lobe function in children with pubertas precox

Gonadotropin-releasing hormone analogues (GnRHa) are frequently used for therapeutic purposes in both adults and children. Previous studies showed that GnRHa therapy may impact cognitive function and behavior in adult humans and pre-pubertally treated animals. This is the first study of GnRHa therapy effects on cognitive function and heart rate variability (HRV) in young humans.

Twenty GnRHa treated girls at age 9-11 and fulfilling central precocious puberty (CPP) criteria are being tested twice; under treatment and 6-12 mo after treatment ending. The patients will be compared to 20 age-matched female and 20 male controls following the same testing procedures, according to cognitive function, behavior, emotional control, and heart rate variability.  We will be discussing the basis of the study, methodology, its current state and challenges.

Conference: WAS Glasgow 2011
Areas of Interest / Categories: Child and Adolescent Health