The objectives of this study were to evaluate the efficacy of vardenafil in men with erectile dysfunction (ED) by measurement of duration of erection leading to successful intercourse. This was a randomised, multicentre, double-blind, placebo-controlled, crossover study.
Inclusion criteria: men aged 18–64 years; ED >6 months‟ duration; International Index of Erectile Function, erectile function domain (IIEF-EF) score >5 and <26. Patients completed a 4-week runing period and were then randomised to 4 weeks‟ treatment with fixed-dose vardenafil 10 mg or placebo. After a 1-week washout period, patients were crossed over to the alternate study medication. Primary efficacy measure: stopwatch-assessed duration of erection (measured from time erection perceived hard enough for penetration until withdrawal from partner‟s vagina) leading to successful intercourse (measured by Sexual Encounter Profile question 3 [SEP3]). Secondary efficacy measures included: IIEF-EF, SEP2 and SEP3.
Intent-to-treat (ITT) population = 191 patients. Patients had ED of varying aetiology and severity (moderate/severe ED, 73%). Baseline underlying conditions included hypertension (32%), diabetes (7%) and hyperlipidemia (10%).
Over 4 weeks’ treatment, least squares mean duration of erection leading to successful intercourse was significantly longer for vardenafil than for placebo (12.81 min vs 5.45 min; p<0.001). Treatment with vardenafil was also superior to placebo in IIEF-EF, SEP2 and SEP3 measures. Vardenafil was well tolerated; the nature and incidence of adverse events were consistent with the previously demonstrated safety profile of vardenafil. Compared with placebo, vardenafil treatment produced a significantly superior duration of erection leading to successful intercourse in men with ED of broad aetiology.
About 10-15 % of adults have the experience of not getting pregnant, when they have a wish to have a child. For some, this life situation is resolved spontaneously. Some undergo investigation, followed by varying treatments, resulting in a child, some adopt, and for others this situation is permanent, and without a solution. When this is the case, existential questions often arise. Earlier studies show that couples who become parent after IVF-treatment are just as content, or more, with their relationships and sexuality compared to parent who conceived spontaneously. Little is known about the couples who continue their relation without a child. Clinical experiences are that many women and men struggle with questions concerning the meaning of sexuality.
In the framework of the Coalition for Sexual and Bodily Rights in Muslim Societies (CSBR) experience to promote sexual, bodily and reproductive health and rights, this paper will explore women's approach to sexuality, sexual health, sexual rights, and sexual pleasure based on the experience of the Human Rights Education Program for Women (HREP) in Turkey, implemented in 42 cities. The paper will contexualize sexual health and rights in Muslim societies through a human rights approach, drawn on experiences of grassroots movement for women in Turkey, in a context where efforts to promote SRHR contend with patriarchal norms and taboos around sexuality.
Legal education in rural India which circumscribes rights of women with special focus on reproductive rights, rape laws, female feticide, domestic violence, child marriage etc. has played a pivotal role in translating these rights into practice. This has been possible through innovative legal education drives which have identified a set of para-legal women who act as reservoirs of knowledge and are adequately equipped to handle instances of violation of such rights.
It is commonly accepted that sex education should start at early age. Most teachers hold positive attitudes towards programs on sex education, but some surveys showed a discrepancy between overt attitudes towards sex education and willingness to practice this as part of the professional duty.
In many school settings, adolescent sexuality has been discussed largely in terms of sexual behaviour and risk. Little attention has been given to the positive aspects of sexuality and sexual expression. This study sought to explore how key stakeholders in three secondary schools in the UK understand youth sexual behaviours.
Does circumcision reduce the risk of HIV transmission? Relationship between male circumcision and HIV infection based on randomized, controlled intervention trial in three
This presentation, "Responding to the needs of consumers with complex trauma histories a consumer perspective" focuses on the needs of adult survivors of child abuse, highlighting the frequent