The processing of our daily potent, enriched and stimulating experiences during sleep and dreaming has been well investigated in recent years at the conscious and neuronal level. Now it is being examined at the deeper levels of gene expression and epigenetic processes. It is known that we are designed to respond and adapt to changing circumstances. Our behaviour, and even our biology changes. Changes also occur at the very fundamental level of our DNA. There has been great interest, recently, in neuroplasticity and now we have insight into gene plasticity. What impact does gene plasticity have on our biological function and behavioural expression? What influence does the mind have? What do we know from the research into these processes and what might we predict – or perhaps dream – into the future? In the same way that neuroscience has opened doorways of progress into the way we practice psychotherapy, so will an understanding of these fundamental processes of activity dependent gene expression. Research from various quarters over the past decade plus the recent experiments and research of the International Psychosocial Research Group will be presented. Beneath what we can consciously grasp is a flawing river of biochemistry that is, perhaps for the moment, far more engaged with our dreams than our will.