Psychodynamic interpersonal therapy was developed and refined over the course of thirty years by Dr RF Hobson, Reader in Psychotherapy at the University of Manchester and a former Training Analyst of the Society of Analytical Psychology in London, and Professor Russell Meares, University of Sydney, New South Wales. A training package and manual were first developed in 1983 (Margison and Hobson, 1983), and a subsequent brief manual and rating scale for the treatment of depression (Shapiro and Startup, 1991) were developed in 1991. Since then the model has been used in a brief format in 13 randomised controlled trials involving the following conditions: depression, self-harm, and medically unexplained symptoms. The talk will review the evidence base for the model, and it’s practical application when working with clients with medically unexplained symptoms. The model has also been shown to be cost-effective for patients who are high utilisers of psychiatric care (Guthrie et al, 1999) and patients with medically unexplained symptoms (Creed et al, 2003).