Radiosynthesis of fluorine-18 labeled GnRH peptide analogues: in vitro studies and in vivo assessment of brain uptake in rats

Radiosynthesis of fluorine-18 labeled GnRH peptide analogues: in vitro studies and in vivo assessment of brain uptake in rats

2013-05-01 00:00:00

GnRH has been shown to have a bidirectional transport through the blood-brain-barrier (BBB), which may explain the cognitive effects of systemically administrated GnRH. The purpose of this study was to synthesize 18F-GnRH peptide analogues in order to investigate basic in vitro characteristic as well as brain uptake by means of positron emission tomography (PET) and biodistribution studies in rats.

Conference: WAS Glasgow 2011
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